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Multiplo TP/HIV is a rapid test for the simultaneous detection of antibodies to HIV-1/2 and/or syphilis in whole blood, serum, and plasma specimens.
Human immunodeficiency virus (HIV) is a blood-borne virus typically transmitted via sexual intercourse, shared intravenous drugs’ needles, and during the birth process or via human milk (vertical transmission). HIV disease is caused by infection with HIV-1 or HIV-2, which are retroviruses in the Retroviridae family, Lentivirus genus.
Signs and symptoms
The patient with HIV may present with signs and symptoms of any of the stages of HIV infection. No physical findings are specific to HIV infection. Manifestations include the following
An estimated 430,000 children were newly infected with HIV in 2008, over 90% of them through mother-to-child transmission (MTCT). Syphilis is a sexually transmitted disease caused by the bacterium Treponema pallidum (TP). Mother-to-child transmission (MTCT) of syphilis is a major cause of adverse pregnancy outcomes. Syphilis and HIV share the common routes of transmission, thus the majority of individuals considered at risk of infection with one of the diseases are consequently at risk with the other one.
The US Preventive Services Task Force (USPSTF) recommends that clinicians screen for HIV in all adolescents and adults at increased risk for HIV infection, and all pregnant individuals.
Syphilis is a sexually transmitted infection caused by the bacterium (spirochete) Treponema pallidum.T pallidum is solely a human pathogen and does not naturally occur in other species. It is primarily spread through sexual contact but can be spread by exposure to blood products and transferred in utero. T pallidum cannot survive drying or exposure to disinfectants; thus, fomite transmission (eg, from toilet seats) is virtually impossible.
After an incubation period of 10 to 90 days (three weeks on average), clinical symptoms appear: the first is a primary lesion at the site of infection (chancre), then a series of eruptions on mucous membranes and skin (secondary syphilis), followed by long periods of latency (latent or tertiary syphilis). If untreated, many years after the initial infection, tertiary syphilis lesions might finally appear (visceral, multi-organ involvement, including serious vascular and neurological damage). Mother-to-child transmission might result in fetal death, perinatal death or congenital syphilis. The latter can be without symptoms or present with stigmata or multi-organ pathology. With the widespread use of penicillin, syphilis prevalence had significantly declined after World War II. However, in several industrialized countries, a considerable resurgence occurred in late 1980.
Because they are both sexually transmitted diseases that can adversely affect both mother and baby and both diseases can be treated. HIV cannot be cured but drugs can slow the progression. However, syphilis can be cured and is best treated early to prevent complications of pregnancy and for mothers because advanced syphilis can be hard to treat and has serious complications.
Multiplo TP/HIV is a single‐use, qualitative immunoassay for the detection of antibodies to Treponema pallidum bacteria (TP), the causative agent of syphilis and/or antibodies to human immunodeficiency virus Type 1 and Type 2 (anti‐HIV‐1/2) in human serum, plasma, and whole blood (fingerstick and venipuncture). Multiplo TP/HIV is intended for use by healthcare professionals as an aid in the diagnosis of infection with TP and/or HIV‐1/2.
Multiplo TP/HIV is a manually performed, visually interpreted, rapid vertical flow immunoassay.
The test cartridge contains an immunoreactive test membrane comprised of specially formulated synthetic peptides coated onto a membrane matrix, which functions to capture anti‐TP and anti‐HIV‐1/2 antibodies present in human serum, plasma and whole blood when a drop of the specimen is applied.
(Fingerstick Whole Blood) Includes a test tray in each pouch
20 Mylar pouches each containing:Fingerstick Whole Blood Specimens
SPECIMEN HANDLING & COLLECTION
TEST PROCEDURE
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Multiplo TP/HIV is a rapid test for the simultaneous detection of antibodies to HIV-1/2 and/or syphilis in whole blood, serum, and plasma specimens.
Human immunodeficiency virus (HIV) is a blood-borne virus typically transmitted via sexual intercourse, shared intravenous drugs’ needles, and during the birth process or via human milk (vertical transmission). HIV disease is caused by infection with HIV-1 or HIV-2, which are retroviruses in the Retroviridae family, Lentivirus genus.
Signs and symptoms
The patient with HIV may present with signs and symptoms of any of the stages of HIV infection. No physical findings are specific to HIV infection. Manifestations include the following
An estimated 430,000 children were newly infected with HIV in 2008, over 90% of them through mother-to-child transmission (MTCT). Syphilis is a sexually transmitted disease caused by the bacterium Treponema pallidum (TP). Mother-to-child transmission (MTCT) of syphilis is a major cause of adverse pregnancy outcomes. Syphilis and HIV share the common routes of transmission, thus the majority of individuals considered at risk of infection with one of the diseases are consequently at risk with the other one.
The US Preventive Services Task Force (USPSTF) recommends that clinicians screen for HIV in all adolescents and adults at increased risk for HIV infection, and all pregnant individuals.
Syphilis is a sexually transmitted infection caused by the bacterium (spirochete) Treponema pallidum.T pallidum is solely a human pathogen and does not naturally occur in other species. It is primarily spread through sexual contact but can be spread by exposure to blood products and transferred in utero. T pallidum cannot survive drying or exposure to disinfectants; thus, fomite transmission (eg, from toilet seats) is virtually impossible.
After an incubation period of 10 to 90 days (three weeks on average), clinical symptoms appear: the first is a primary lesion at the site of infection (chancre), then a series of eruptions on mucous membranes and skin (secondary syphilis), followed by long periods of latency (latent or tertiary syphilis). If untreated, many years after the initial infection, tertiary syphilis lesions might finally appear (visceral, multi-organ involvement, including serious vascular and neurological damage). Mother-to-child transmission might result in fetal death, perinatal death or congenital syphilis. The latter can be without symptoms or present with stigmata or multi-organ pathology. With the widespread use of penicillin, syphilis prevalence had significantly declined after World War II. However, in several industrialized countries, a considerable resurgence occurred in late 1980.
Because they are both sexually transmitted diseases that can adversely affect both mother and baby and both diseases can be treated. HIV cannot be cured but drugs can slow the progression. However, syphilis can be cured and is best treated early to prevent complications of pregnancy and for mothers because advanced syphilis can be hard to treat and has serious complications.
Multiplo TP/HIV is a single‐use, qualitative immunoassay for the detection of antibodies to Treponema pallidum bacteria (TP), the causative agent of syphilis and/or antibodies to human immunodeficiency virus Type 1 and Type 2 (anti‐HIV‐1/2) in human serum, plasma, and whole blood (fingerstick and venipuncture). Multiplo TP/HIV is intended for use by healthcare professionals as an aid in the diagnosis of infection with TP and/or HIV‐1/2.
Multiplo TP/HIV is a manually performed, visually interpreted, rapid vertical flow immunoassay.
The test cartridge contains an immunoreactive test membrane comprised of specially formulated synthetic peptides coated onto a membrane matrix, which functions to capture anti‐TP and anti‐HIV‐1/2 antibodies present in human serum, plasma and whole blood when a drop of the specimen is applied.
(Fingerstick Whole Blood) Includes a test tray in each pouch
20 Mylar pouches each containing:Fingerstick Whole Blood Specimens
SPECIMEN HANDLING & COLLECTION
TEST PROCEDURE