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MA2035

Malaria Rapid Test: falciparum or vivax

This cassette test kit is a rapid and convenient immunochromatographic assay for the qualitative detection of P.f versus P.v. The CE-marked test kit allows point of care testing using high quality tests made in North America and held to the highest sensitivity and specificity standards.

  • Antigen-capture immunochromatographic assay
  • Can be used with whole blood or serum samples
  • Results ready in 20-30 minutes

THE PROBLEM

Malaria is endemic in multiple regions of the world and remains a leading killer of infants, children and mothers. Pregnancy is a particularly vulnerable time to contract malaria and treatment is essential for mother and fetus. For a pregnant woman and fetus, a malaria infection during pregnancy can lead to maternal anemia, spontaneous abortion, stillbirth, premature delivery, and low-birth weight - a leading cause of infant mortality. Infants who contract malaria are at an increased risk of rapid disease progression, severe anemia, severe malaria, and death. P. falciparum malaria causes more severe disease, mortality and morbidity so it is key to understand which strain a person has contracted in order to be able to best treat them.

THE SOLUTION

This cassette test kit is a rapid and convenient antigen-capture immunochromatographic assay for the qualitative detection of Plasmodium falciparum (P.f) versus Plasmodium vivax (P.v) in whole blood or in serum samples. It differentiates between these two different strains of malaria by detecting the presence of two specific soluble proteins that are released from infected red blood cells - histidine-rich protein II (HRP-II) specific for Plasmodium falciparum (P.f) and lactate dehydrogenase (pLDH) specific for Plasmodium vivax (P.v). 

To test, a sample of blood or serum is pipetted to the sample well of the test and a buffer is added to the buffer well. The test works by detecting these two specific soluble proteins in the blood or serum sample as it flows through the assay by first, monoclonal antibodies specifically against pLDH and HRP-II, respectively, and conjugated with colloidal gold that attach to these proteins and provide a “visual tag” and second, by two separate test lines - one with immobilized monoclonal antibodies specifically against pLDH and one with immobilized monoclonal antibodies specifically against HRP-II - that capture the relevant protein-antibody-gold complex. When a test line becomes concentrated with complexes, the concentrated visual tag produces a visible colored band that is confirmation of the presence of the target molecule (pLDH or HRP-II) and therefore, the strain of malaria infection. Results are ready in 20-30 minutes. 

Detecting which strain will aid in ensuring those infected with malaria get the most effective course of treatment. This is especially important for a pregnant woman and fetus who are at risk for poor birth outcomes.

Style

This cassette test kit is a rapid and convenient immunochromatographic assay for the qualitative detection of P.f versus P.v. The CE-marked test kit allows point of care testing using high quality tests made in North America and held to the highest sensitivity and specificity standards.

  • Antigen-capture immunochromatographic assay
  • Can be used with whole blood or serum samples
  • Results ready in 20-30 minutes

THE PROBLEM

Malaria is endemic in multiple regions of the world and remains a leading killer of infants, children and mothers. Pregnancy is a particularly vulnerable time to contract malaria and treatment is essential for mother and fetus. For a pregnant woman and fetus, a malaria infection during pregnancy can lead to maternal anemia, spontaneous abortion, stillbirth, premature delivery, and low-birth weight - a leading cause of infant mortality. Infants who contract malaria are at an increased risk of rapid disease progression, severe anemia, severe malaria, and death. P. falciparum malaria causes more severe disease, mortality and morbidity so it is key to understand which strain a person has contracted in order to be able to best treat them.

THE SOLUTION

This cassette test kit is a rapid and convenient antigen-capture immunochromatographic assay for the qualitative detection of Plasmodium falciparum (P.f) versus Plasmodium vivax (P.v) in whole blood or in serum samples. It differentiates between these two different strains of malaria by detecting the presence of two specific soluble proteins that are released from infected red blood cells - histidine-rich protein II (HRP-II) specific for Plasmodium falciparum (P.f) and lactate dehydrogenase (pLDH) specific for Plasmodium vivax (P.v). 

To test, a sample of blood or serum is pipetted to the sample well of the test and a buffer is added to the buffer well. The test works by detecting these two specific soluble proteins in the blood or serum sample as it flows through the assay by first, monoclonal antibodies specifically against pLDH and HRP-II, respectively, and conjugated with colloidal gold that attach to these proteins and provide a “visual tag” and second, by two separate test lines - one with immobilized monoclonal antibodies specifically against pLDH and one with immobilized monoclonal antibodies specifically against HRP-II - that capture the relevant protein-antibody-gold complex. When a test line becomes concentrated with complexes, the concentrated visual tag produces a visible colored band that is confirmation of the presence of the target molecule (pLDH or HRP-II) and therefore, the strain of malaria infection. Results are ready in 20-30 minutes. 

Detecting which strain will aid in ensuring those infected with malaria get the most effective course of treatment. This is especially important for a pregnant woman and fetus who are at risk for poor birth outcomes.

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